Protein Details: Acid-sensing ion channel 2

Protein ID

ICDB_Pro_1374

Protein Name

Acid-sensing ion channel 2

Gene Name

Asic2; Accn1; Bnac1

Organism

Mus musculus (Mouse)

Length

512 amino acids

AlphaFoldDB

AF-Q925H0-F1-model_v4.pdb

Function

Cation channel with high affinity for sodium; which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Sequence

MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed by sensory neurons. Expressed by nociceptive sensory neurons; spiral ganglion (SG) neurons and the retina (at protein level). Isoform 1 and isoform 2 are expressed in outer nuclear layer of retina (photoreceptors) and to a lower extent in distal and proximal inner nuclear layer. Isoform 1 and isoform 2 are expressed in outer nuclear layer of retina (photoreceptors) and to a lower extent in distal and proximal inner nuclear layer. Isoform 1 and isoform 2 are expressed in outer nuclear layer of retina (photoreceptors) and to a lower extent in distal and proximal inner nuclear layer.

DOI ID

10.1074/jbc.272.47.29778; 10.1523/jneurosci.21-08-02678.2001; 10.1371/journal.pbio.1000112; 10.1074/jbc.m407708200; 10.1523/jneurosci.4698-03.2004; 10.1523/jneurosci.3196-04.2004; 10.1016/j.neuroscience.2004.11.030; 10.1038/emboj.2012.203

RefSeq

NP_001029185.1 [Q925H0-1]; NP_031410.1 [Q925H0-2]